We determine the structure of generalized parton distributions from light-front holographic QCD up to a universal reparametrization function w(x), which incorporates Regge behavior at small-x and inclusive counting rules at large-x. A simple ansatz for w(x) which fulfills the physical constraints leads to precise descriptions of both nucleon and pion valence quark distribution functions. The analytic structure provides a nontrivial connection with hadron spectrum. Keeping the holographic structure, we can unambiguously introduce quark masses, preserving the harding scattering counting rule at large-Q and the inclusive counting rule at large-x. Within the light-front holographic framework, we predict the nucleon strange quark form factor and the asymmetric strange sea distribution up to a normalization factor. Together with lattice QCD data, we derive a lower limit on the intrinsic strange sea of the nucleon..