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(Seminar) Translocation of small molecules through engineered outer-membrane channels from Gram-negative bacteria
2018-09-27     Text Size:  A

CAS Key Laboratory of Theoretical Physics

Institute of Theoretical Physics

 Chinese Academy of Sciences

Seminar

Title

题目

Translocation of small molecules through engineered outer-membrane channels from Gram-negative bacteria

Speaker

报告人

Mathias Winterhalter

Affiliation

所在单位

Department of Life Sciences and Chemistry,Jacobs University Bremen,D-28719 Bremen, Germany.

Date

日期

2018年9月27日(周四)下午4:30

Venue

地点

Conference Hall 6620, ITP new building/理论物理所新楼6620报告厅

Abstract

摘要

Selective permeability is one of the key features of biological membranes. The permeability for small water soluble molecules is controlled on one hand by physico-chemical properties of the lipid bilayer and on the other hand by channel-forming membrane proteins. To transfer the unique properties of natural or artificial channels into technical application a new field emerged called nanopores. The main driving force in this area has been the application of natural pore-forming proteins to transform information stored chemically in the DNA sequence directly into an electric signal in form of a time-dependent ion current. An obvious extension is to use the intrinsic selectivity of channels to detect proteins, peptides or small molecules. Our group is quantifying the uptake of antibiotics into bacteria. For this we extract channels from the outer cell wall of bacteria, reconstitute them into artificial bilayer and characterizing the permeation of small molecules across them.

Contact person

所内联系人

欧阳钟灿

 

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