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| Peptide and Membrane: Molecular Engineering of Melittin for Enhanced Antibacterial Activity |
| 2018-09-05
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CAS Key Laboratory of Theoretical Physics |
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Institute of Theoretical Physics |
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Chinese Academy of Sciences |
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Seminar |
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Title
题目 |
Peptide and Membrane: Molecular Engineering of Melittin for Enhanced Antibacterial Activity |
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Speaker
报告人 |
元冰 |
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Affiliation
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Date
日期 |
2018年9月5日（周三）下午14:00 |
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Venue
地点 |
Conference Room 6520, ITP new building |
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Abstract
摘要 |
In face of the devastating threat of drug-resistant bacteria to public health, antimicrobial peptides (AMPs) promise a fundamental solution due to their unique antibacterial mechanism via directly disrupting the bacterial membrane. However, the drawbacks of AMPs such as poor bactericidal efficiency and high cytotoxicity block the efforts to bring them into clinical use. To engineer AMPs with nanotechnology is a promising strategy to solve these problems. In this work, hybrid complexes composed of melittin, as one of the most representative AMPs, and 2D graphene or graphene oxide (Gra or GO) nanosheets are designed to enhance the membrane perforation efficiency for improved antibacterial activity, by making full use of the resemblance between Gra/GO nanosheets and melittin in antibacterial mechanism. Tests in both simulations and experiments demonstrate that, once melittin is decorated at the edge of Gra/GO nanosheets, the as-fabricated complex projects remarkable efficiency in transmembrane poration, due to the synergetic insertion of melittin and nanosheets. Influences of structural modulation of the complex are further discussed, which promise the practical fabrication even with further improved performances for clinical use, after further functionalization of the Gra/GO nanosheets of the complex. Molecular mechanism during the peptide-membrane interactions is further given. |
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Contact person
所内联系人 |
Yanting Wang |
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