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| Coarse-grained modeling for 3D structure and stability of RNAs in salt solutions |
| 2018-08-03
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CAS Key Laboratory of Theoretical Physics |
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Institute of Theoretical Physics |
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Chinese Academy of Sciences |
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Seminar |
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Title
题目 |
Coarse-grained modeling for 3D structure and stability of RNAs in salt solutions |
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Speaker
报告人 |
谭志杰 |
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Affiliation
所在单位 |
武汉大学物理系 |
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Date
日期 |
2018年8月3日（周五）上午10:30 |
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Venue
地点 |
中国科学院理论物理研究所新楼6520会议室 |
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Abstract
摘要 |
Three-dimensional (3D) structures and their stability are essential for the biological functions of RNAs, and due to the polyanionic nature, salt condition is critical for RNA 3D structure and stability. However, there is still lack of a unified 3D structure prediction model for predicting 3D structure and stability of RNAs in salt solutions. In the work, we have proposed a coarse-grained model for predicting 3D structure and stability of RNAs, including RNA hairpins, duplexes and RNA pseudoknots, and the model can account for the effect of monovalent and divalent ions on their structures and stability. The predicted 3D structures, and melting temperatures for RNA hairpins, duplexes and pseudoknots in various monovalent/ divalent ion solutions are in excellent agreement with the extensive experimental measurements. |
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Contact person
所内联系人 |
王延颋 |
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