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| (Seminar) Structural organization and energy storage in crosslinked actin-assemblies |
| 2018-04-11
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CAS Key Laboratory of Theoretical Physics |
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Institute of Theoretical Physics |
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Chinese Academy of Sciences |
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Seminar |
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Title
题目 |
Structural organization and energy storage in crosslinked actin-assemblies |
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Speaker
报告人 |
马锐 |
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Affiliation
所在单位 |
耶鲁大学 |
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Date
日期 |
2018年4月11日（周三）下午16：00 |
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Venue
地点 |
ITP New Building 6420 |
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Abstract
摘要 |
Clathrin-mediated endocytosis (CME) is necessary for cells to internalize extracellular cargo, by invaginating a patch of membrane and releasing a vesicle into the cytoplasm. In yeast, this process is mediated by the robust self-assembly of clathrin and over 60 other proteins, including actin, actin-associated proteins, and membrane proteins. This membrane deformation is counteracted by membrane tension and high turgor pressure, presenting a large energy barrier to internalization. Importantly, a dynamic actin meshwork is required for successful CME in yeast, leading to the conclusion that the actin machinery produces forces to drive the membrane invagination. In this talk, I will present our recent simulations on the self-organization rigid actin filaments in the presence of elastic crosslinkers in conditions relevant for endocytosis. Our simulations demonstrated that these nanometer-scale actin structures can store a large amount of elastic energy within the crosslinkers. This conversion of binding energy into elastic energy is the consequence of geometric constraints created by the helical pitch of the actin filaments, which results in frustrated configurations of crosslinkers attached to filaments. We propose that this stored elastic energy can be used at a later time in the endocytic process. |
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Contact person
所内联系人 |
欧阳钟灿 |
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