Home | Contact | Sitemap | 中文 | CAS
Search: 
Home │  About Us │  Research │  People │  International Cooperation │  Education & Training │  Papers
  Seminar
Conference
Forum on FS
Colloquium
Seminar
Lunch Seminar
Coffee Time
Advanced Course
KITPC Activities
Other activities
  Location: Home >  Research Activities >  Seminar
Stochasticity and robustness in S-phase duration from genome replication kinetics
2016-09-13     Text Size:  A

Institute of Theoretical Physics

Key Laboratory of Theoretical Physics

  Chinese Academy of Sciences

Seminar

Title

题目

Stochasticity and robustness in S-phase duration from genome replication kinetics

Speaker

报告人

Qing Zhang

Affiliation

所在单位

Universite Pierre et Marie Curie, Paris
 

Date

日期

13 September 2016, Tuesday: 10:30--11:30
 

Venue

地点

理论物理所新楼6420报告厅

Abstract

摘要

Genome replication, a key physiological process for a living cell, typically relies on intrinsically stochastic initiation by replication origins, causing a variability of replication timing from cell to cell. Over evolution, an organism can control only the propensity of origins to initiate and their position, but it does not eliminate completely this uncertainty. While widely accepted mathematical models of eukaryotic replication as a stochastic process are available, the question of the link between the controllable parameters and the resulting distribution of global replication timing has not been addressed systematically.
Here, we propose a combined analytical and computational approach to this question. Our calculations give a simple way to understand how positions and strengths of many origins lead to a given distribution of total duration of the replication of a large region, a chromosome or the entire genome. Specifically, the total replication timing can be framed as an extreme-value problem, since it is due to the last region that replicates in each cell. Our calculations lead us to identify two regimes based on the spread between characteristic completion times of all inter-origin regions of a genome. For widely different completion times, timing is set by the single specific region that is typically the last to replicate in all cells (and is hence "fragile"). Conversely, when the completion times of all regions are comparable, an extreme-value estimate shows that the cell-to-cell variability of genome replication timing has universal properties. Comparison with available data shows that the replication program of two yeast species falls in this extreme-value regime.

Contact person

所内联系人

Hai-Jun Zhou
 

  Appendix:
       Address: No. 55 Zhong Guan Cun East Road, Haidian District, Beijing 100190, P. R. China
Copyright ? Institute of Theoretical Physics, Chinese Academy of Sciences, All Rights Reserved