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Institute of Theoretical Physics |
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Chinese Academy of Sciences |
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State Key Laboratory of Theoretical Physics |
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Seminar |
| |
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Title
题目 |
Hierarchical feedback modules and hubs of bionetworks through graph decomposition |
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Speaker
报告人 |
Professor Yueheng Lan (兰岳恒) |
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Affiliation
所在单位 |
Physics Department, Tsinghua University |
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Date
日期 |
2015年10月26日（周一）16：00 |
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Venue
地点 |
ITP New Building 6420, 理论物理研究所新楼四层多媒体教室 |
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Abstract
摘要 |
Through the analysis of forward and feedback links of a biochemical network based on the input-output polarity
and the principle of optimal usage of resources, we are able to decompose a large network into modules. For
signal transduction network, a hierarchical structure of feedbacks is identified with local feedbacks exerting quick
strong control and the global ones adjusting the dynamics in a slow and subtle way. Moreover, at the fork of forward
pathways or the intersection of the forward and feedback edges, signaling hubs are often detected which constitute
bottlenecks of the whole network. |
