We study the properties of inhomogeneous semiflexible biopolymers. We show exactly that when free of external force, a semiflexible biopolymer with short range correlations in the sequence-disorder intrinsic curvatures and torsions is equivalent to a biopolymer with well-defined (i.e., without randomness) intrinsic curvature and torsion as well as renormalized persistence lengths. We find an exact expression for the distribution function of a two-dimensional inhomogeneous semiflexible biopolymer and use it to evaluate the bending profile. Our results agree well with bending profiles of dsDNA with long-range correlation in base pairs. However, we show that an “equivalent system” does not always exist for the biopolymer under external force. We find that under an external force, the effect of sequence-disorder depends upon the averaging order, the degree of disorder, and the experimental conditions.