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Superselectivity comes from multivalency

11/24 2023 Seminar
  • Title Superselectivity comes from multivalency
  • Speaker Xiu-Yang Xia (Nanyang Technological University)
  • Date 10:00 Nov. 24, 2023
  • Venue North Building 322
    • Abstract
    The foundation of numerous biological processes lies in the utilization of multiple weak connections to effectively establish strong interactions, a phenomenon known as multivalent interactions. This not only strengthens binding but also leads to the super-linear increase in adsorption of guests with environmental parameter changes, a phenomenon termed superselectivity [1]. Superselectivity plays a pivotal role in determining the fate of nano-medicines in biological environments, client recruitment in biomolecular condensates, and DNA array detection assays, etc. In this talk, I will provide a comprehensive understanding of the superselectivity of both direct multivalent binding [1,2] and indirect linker-mediated bridging [3]. I will illustrate an unexpectedly high receptor concentration-dependent selectivity that occurs under uniform receptor distributions in direct multivalent binding. Additionally, I will discuss the design principles of bridging energy and linker density-dependent superselectivity in indirect linker-mediated bridging.

    [1] F. J. Martinez-Veracoechea and D. Frenkel, PNAS 108, 10963 (2011).
    [2] X. Xia, G. Zhang, M. Pica Ciamarra, Y. Jiao, and R. Ni, JACS Au 3, 1385 (2023).
    [3] X. Xia, and R. Ni, arXiv:2310.15834 (2023).

    Invitor：
    Fanlong Meng