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(online-Seminar)Spatiotemporal self-organization in living systems at multi-scales
09/03
2020
- Title (online-Seminar)Spatiotemporal self-organization in living systems at multi-scales
- Speaker
- Date
- Venue
Abstract
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CAS Key Laboratory of Theoretical Physics | |||
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Institute of Theoretical Physics | |||
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Chinese Academy of Sciences | |||
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Seminar | |||
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Title 题目 |
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Speaker 报告人 |
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Affiliation 所在单位 |
Department of Physics, University of California, San Diego | ||
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Date 日期 |
2020年9月3日（星期四）10:30am - 11:30am | ||
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Venue 地点 |
腾讯会议ID: 554 811 019 | ||
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Contact Person 所内联系人 |
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Abstract 摘要 |
Despite the huge differences in spatiotemporal scales, the processes in living systems share a common feature--self-organization. As physicists, we are provided and are developing a lot of tools to understand the principles of complex self-organization in biology. I will talk about three stories about self-organization from molecular, to cellular and multi-cellular scales. At the molecular level, I will focus on the synchronization of molecular clocks, from the perspective of phase transition and free energy consumption. I will show that the synchronization of noisy molecular clocks costs additional free energy which explains the puzzle of ATPase activities in the cyanobacterial circadian clock. At the cellular level, I will describe a minimal model with simple mechanochemical coupling to explain the complex plasticity of cell migration. The model predictions are verified by cell experiments. At the multi-cellular level, I will discuss the formation of a beautiful flower-like pattern in a bacterial colony. The pattern formation can be understood by the mechanical instability caused by bacterial growth and motility. The physical principles in these studies can be further applied to fundamental studies such as biological information processing and clinical studies such as cancer metastasis. | ||