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(Seminar) A rule based approach to Development

04/10 2018
  • Title (Seminar) A rule based approach to Development
  • Speaker
  • Date
  • Venue
  • Abstract

    CAS Key Laboratory of Theoretical Physics

    Institute of Theoretical Physics

     Chinese Academy of Sciences

    Seminar

    Title

    题目

    A rule based approach to Development

    Speaker

    报告人

    Prof. Kim Sneppen 

    Affiliation

    所在单位

    Niels Bohr Institute, Danmark

    Date

    日期

    4月10日(星期二)10:30 -11:30

    Venue

    地点

    ITP New Building 6420

    Abstract

    摘要

    Development of animals proceeds from bulk, through simple spherical shapes to folds and tubes. Emerging geometrical shapes are robust for a given species and can be maintained when moved to different parts of the embryo or if the size is varied. Despite conceptually similar processes of progression through development, the resulting geometrical shapes can be very different between species. How can we reconcile this robustness with overall variability? The progression from  bulk, to tubes and folds coincides with the progressive  - first apical basal and then planar -- polarization of cells. To explore if cellular polarization may enable development with the ability to create diversity of robust and stable shapes we developed a tool that allows to simulate thousands of polarized cells in 3D. We find that cellular polarity enables stable complex folded shapes. When set in the context of pancreatic organoids, one polarity (Apical basal) coupled with differential growth rates is sufficient to explain emergence of folded lumens in pancreatic organoids. With two, apical basal and planar, mutually perpendicular polarities, the model recovers main stages of sea urchin gastrulation.

    Contact person

    所内联系人

    Hai-Jun Zhou